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Global Biotechnology Insights
Posted on September 14, 2020 by  & 

Wearable Offers Options for Treating Antibiotic-Resistant Infections

The rapid increase of life-threatening, antibiotic-resistant infections has resulted in challenging wound complications with limited choices of effective treatments. About 6 million people in the United States are affected by chronic wounds. Now, a team of innovators from Purdue University has developed a wearable solution that allows a patient to receive treatment without leaving home. The Purdue team's work is published in the journal Frontiers in Bioengineering and Biotechnology.
 
"We created a revolutionary type of treatment to kill the bacteria on the surface of the wound or diabetic ulcer and accelerate the healing process," said Rahim Rahimi, an assistant professor of materials engineering at Purdue. "We created a low-cost wearable patch and accompanying components to deliver ozone therapy."
 
Ozone therapy is a gas phase antimicrobial treatment option that is being used by a growing number of patients in the U.S. In most cases, the ozone treatments require patients to travel to a clinical setting for treatment by trained technicians. For further information see the IDTechEx report on Advanced Wound Care Technologies 2020-2030.
 
"Our breathable patch is applied to the wound and then connected to a small, battery powered, ozone-generating device," Rahimi said. "The ozone gas is transported to the skin surface at the wound site and provides a targeted approach for wound healing. Our innovation is small and simple to use for patients at home."
 
 
The team worked with the Purdue Research Foundation Office of Technology Commercialization to patent the technology. The creators are looking for partners to continue developing their technology.
 
Abstract
Wearable and Flexible Ozone Generating System for Treatment of Infected Dermal Wounds: Wound-associated infections are a significant and rising health concern throughout the world owing to aging population, prevalence of diabetes, and obesity. In addition, the rapid increase of life-threatening antibiotic resistant infections has resulted in challenging wound complications with limited choices of effective therapeutics. Recently, topical ozone therapy has shown to be a promising alternative approach for treatment of non-healing and infected wounds by providing strong antibacterial properties while stimulating the local tissue repair and regeneration. However, utilization of ozone as a treatment for infected wounds has been challenging thus far due to the need for large equipment usable only in contained, clinical settings. This work reports on the development of a portable topical ozone therapy system comprised of a flexible and disposable semipermeable dressing connected to a portable and reusable ozone-generating unit via a flexible tube. The dressing consists of a multilayered structure with gradient porosities to achieve uniform ozone distribution. The effective bactericidal properties of the ozone delivery platform were confirmed with two of the most commonly pathogenic bacteria found in wound infections, Pseudomonas aeruginosa and Staphylococcus epidermidis. Furthermore, cytotoxicity tests with human fibroblasts cells indicated no adverse effects on human cells.
 
 
 
Source and top image: Purdue University
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