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Global Biotechnology Insights
Posted on March 17, 2021 by  & 

Remote Controlled Microscale Robots to Deliver Drugs

Bionaut Labs, a company focused on revolutionizing the treatment of central nervous system disorders (CNS) with its Bionaut precision medicine treatment modality, announced its launch backed by $20 million financing led by Khosla Ventures. Other investors in the syndicate included Upfront Ventures, Revolution, BOLD Capital, and Compound. Proceeds from the financing support the advancement of the Company's lead therapeutic program in glioma through preclinical development, as well as help advance its program in Huntington's disease.
"We are thrilled to bring Bionaut Labs out of stealth mode as it typifies the type of new impactful technology companies we like to help build," said Vinod Khosla, founder, Khosla Ventures. "Bionauts hold great promise as a new targeted treatment modality for severe brain disorders for which there are few, if any, effective treatment options. Moreover, the broad therapeutic potential of Bionauts™ extends to many diseases where conventional therapies are limited or lacking."
A Bionaut is a novel treatment modality that uses remote-controlled microscale robots to deliver biologics, nucleic acids, or small molecule therapies locally to targeted CNS disease areas. Through precision localized brain targeting, Bionaut therapeutics could offer better efficacy and safety that cannot be achieved by other traditional treatment modalities. For further information see the IDTechEx report on Mobile Robots, Autonomous Vehicles, and Drones in Logistics, Warehousing, and Delivery 2020-2040.
"Bionauts can transform the way the biopharmaceutical industry develops treatments, allowing us to engineer the therapeutic index for improved efficacy and better safety," said Michael Shpigelmacher, co-founder and CEO, Bionaut Labs. "The Bionaut approach allows us to be free of the constraints of conventional neurosurgery. They make it possible to get to the precise brain area we want to target, providing the freedom to explore new pathways and remove the device without leaving a footprint. We are extremely pleased to debut with the strong support of this world-class syndicate, to fulfill our mission of helping patients suffering from debilitating brain diseases who lack treatment options."
Bionauts can be constructed in different versions with custom geometries and surface characteristics. Smaller than a millimeter, they contain moving parts controlled remotely by a magnetic controller, allowing them to safely reach the target and release a therapeutic payload from the cargo compartment. Engineering flexibility provides a broad foundation for designing Bionaut™ therapies for nearly any disease of interest.
"The brain is uniquely designed to protect itself from external factors. This makes medical intervention in CNS extremely challenging. The Bionaut technology opens the door to precise treatment for a wide variety of severe brain disorders," said Santosh Kesari, MD, PhD, Chair of the Department of Translational Neurosciences, Director of Neuro-Oncology at St. John's Cancer Institute, and a member of Bionaut Lab's Advisory Board.
Brainstem glioma remains one of the most devastating tumors, predominantly affecting children and young adults. Conventional treatment for brainstem glioma offers modest gains in overall survival, but overwhelmingly fails to cure these young patients. Bionaut Labs has demonstrated safe and controlled navigation of its therapeutic Bionaut to and from the treatment locus in the brain, in a large animal in vivo model. Furthermore, the Company has successfully treated human glioma tumors established in mice, utilizing guided delivery of therapeutic cargos directly into these tumors to eliminate systemic toxicity. These results pave the way to the clinical trials of the Bionaut platform.
"Bionauts enable safe, minimally invasive access to deep brain structures to treat CNS disorders by facilitating precise delivery of therapeutic agents. This approach enhances efficacy and eliminates off-target toxicity, while also allowing the targeting of a wide range of localized diseases with almost any type of therapy. What's even more exciting is that the anatomical targeting capabilities of the Bionaut™ platform make new therapeutic technologies such as antisense, siRNA, gene therapy, CRISPR-Cas9, and oncolytic viruses viable in challenging clinical settings," added Errol DeSouza, Ph.D., co-founder, Neurocrine Biosciences, and Head of Bionaut Labs' Advisory Board.
"Bionaut Labs takes drug development to the next level with its Bionaut precision treatment modality, enabling full control over the therapeutic index. It shortens the time to market for new drugs and potentially even revives discarded drugs," said Aviad Maizels, cofounder and Executive Chairman, Bionaut Labs. "It is the perfect merge of engineering and biology."
Source and top image: Bionaut Labs
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